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- Thiopurine methyltransferase (TPMT): A blood test for thiopurine methyltransferase (TPMT), which metabolizes thiopurine compounds such as azathioprine, helps identify patients at risk of toxicity from drugs like azathioprine. Most people have normal TPMT enzyme activity and respond well to normal doses of thiopurines. A small percent of people have one copy of a variant allele, or are severely deficient in TMPT, which results in an increased risk of drug toxicity.
- Thrombocytopenia: Low platelet count.
- Thrombosis: A blood clot.
